Life in the Lab: Perspectives on Graduate School
Author: Vanessa Parise
The Neuroscience program at McMaster University is diverse and interdisciplinary, which can make it feel a little daunting when you're first starting out. To offer some perspective from students who've been through it, I sat down with two of our senior students, Mahmoud Elsayed and Peter Najdzionek, to talk about how they found their way into the field, how they handle the stress of research, and what they wish someone had told them before they started.

Mahmoud is a senior PhD student under the supervision of Dr. James MacKillop in the Peter Boris Centre of Addictions Research (PBCAR) located at St. Joesph Healthcare Hamilton West 5th Campus. He is currently in the process of writing his dissertation. Mahmoud's work centers on developing novel methodological approaches that bring together neuroimaging, machine learning, and behavioural genetics

Peter is a senior PhD student under the supervision of Dr. James MacKillop in the Peter Boris Centre of Addictions Research (PBCAR) located at St. Joesph Healthcare Hamilton West 5th Campus. He is currently in the process of wrapping up his 3rd project and aims to begin writing his dissertation in the coming months. Peter studies the longitudinal associations between cannabis use and cognition and brain structure in emerging adults.
How They Got Here
Both Mahmoud and Peter moved to Canada to pursue their studies. Peter began his graduate journey in 2020, starting his Master's in Neuroscience at McMaster, while Mahmoud began his PhD studies in 2022.
What sparked your interest in neuroscience, and why this program?
Mahmoud: I have always been fascinated by the human brain... that peculiar lump of matter which somehow composes symphonies, builds civilizations, falls in love, invents machine learning, and then forgets where it left its keys. Neuroscience seemed the natural place to investigate this contradiction. I did not originally intend to study neuroscience at McMaster; my background was in engineering and machine learning. As fortune would have it, a faculty member was searching for a student with precisely that expertise. The timing aligned rather elegantly... or, at the very least, less disastrously than most things in life.
Peter: I came in with a psych degree, but my participation in a behavioural toxicology lab pulled me toward the biological side of psychology as I really enjoyed that experience. McMaster is one of the top research universities in Canada, and publications and research experience are crucial for success in this field. I felt McMaster could give me that foundation.
A Day in the Life
What does a typical day look like for you?
Mahmoud: I am also completing a master’s degree part-time, so my days begin at approximately seven in the morning... an hour at which neither the soul nor the nervous system has given informed consent to consciousness. I make my way to the laboratory at St. Joe’s and remain there until around five. Three evenings each week, I then travel to campus for classes. Upon returning home, I answer whichever emails have multiplied in my absence and conclude the day with some reading. It is a rather full existence... but life is short, and we have got to make the most out of it.
Peter: I start by assessing my calendar and figuring out top priorities for the week. I do my best work in the morning, so anything cognitively demanding, like reading key research articles or manuscript writing, happens then. I usually have one or two meetings a day, and I keep lighter work for the afternoon. I try not to work past 5pm.
Stress, Uncertainty, and Learning Balance
How do you manage stress, uncertainty, or work-life balance?
Mahmoud: My guiding principle is rather simple: if I cannot change something, worrying about it is merely suffering twice... once in imagination and once, perhaps, in reality. Uncertainty is not an unfortunate interruption to the human condition; it is the human condition. We are cast into an incomprehensibly vast universe without instructions, guarantees, or even reliable access to objective reality... yet we remain terribly surprised whenever life refuses to follow our plans. Imposter syndrome is equally ordinary. It is uncomfortable, certainly, but it can also teach humility. As children, we imagine our parents to be invincible figures who understand the machinery of existence. Then we grow older and discover that they, too, were improvising. The same revelation eventually occurs in graduate school: the senior students, professors, and distinguished scholars who appear to possess secret knowledge are usually just fellow travellers who have become slightly better at concealing their confusion. As for work-life balance, I am not entirely convinced that life and work can be placed neatly upon opposite sides of a scale. The more sustainable approach is to weave them together... to make one’s work part of a meaningful life without permitting it to consume the whole of it. Beyond the laboratory, I remain connected with friends scattered across the world, practise hot yoga, dine with friends, and retreat into classical music and quiet works of nonfiction. One must occasionally remind oneself that the universe existed before the latest deadline... and will, rather rudely, continue after it.
Peter: It's easy to lump stress and uncertainty together, since one can cause the other. I try to separate actionable items from unactionable, and not stress about the unactionable ones, since that just eats into precious cognitive capacity. Actionable stress is trickier though. Just because you can do something doesn't mean you should; I try to maximize efficiency. For example, blocking off 1-2 hours in my calendar for a specific task yields better results than leaving an open stretch of time. If I'm stressed, it kind of ruins my day, I start to dissociate and it eats away at my attention and mood. So, I focus on what must be finished versus what can be finished in the future. Identifying when I’m working inefficiently and stopping helps with stress and work-life balance. Being off the clock is the best time to work on yourself and do things you're interested in, for me that's cooking, playing volleyball, and video games with friends.
Challenges and Unexpected Lessons
Were there any major challenges or setbacks? How did you work through them?
Mahmoud: My intial supervisor left during my first year, which required me to change supervisors and redirect the course of my PhD. At the time, it appeared to be a significant disruption, although I navigated it more smoothly than I might have expected. Beyond that, research offers a fresh collection of smaller inconveniences each day... analyses that fail, code that revolts, manuscripts that return decorated in reviewer comments, and computers that choose moments of particular importance to develop philosophical objections to functioning. One simply meets these difficulties as they arrive. My brother once advised me not to take life too seriously, and a friend later offered the same wisdom. When identical advice arrives from independent sources, one ought perhaps to treat it as a replicated finding. We are temporary creatures attempting to impose order upon chaos... becoming excessively solemn about the enterprise seems almost impolite.
Peter: Challenges come in all shapes and sizes; everything from a frustrating code debugging to a publication getting scooped. Each one needs a different approach. As a general rule of thumb, I try to work through things myself first, and if I require more help, I reach out to a peer with documentation of what I've already tried.
What's been your biggest professional growth moment?
Mahmoud: I cannot identify a single defining moment. Growth has been less like a sudden revelation and more like erosion... slow, quiet, and visible only after time has passed. There have been milestones, certainly, but I have never regarded them as final destinations. Each achievement merely reveals another stretch of road, another question, and another previously undiscovered variety of ignorance. I am always learning... which is either the great privilege of this profession or its most elaborate practical joke.
Peter: Looking back, it stops being about major events and becomes more about the accumulation of small ones over time. I don't think I could pinpoint one big moment.
Advice for New Students
What do you wish you had known when starting your degree?
Mahmoud: I would tell my younger self that things will, in all likelihood, work themselves out. You will learn as you proceed, adapt to the unfamiliar, and eventually catch up with those whom you mistakenly imagine are far ahead of you. Every new environment initially feels like a performance for which everyone else received the script. They did not. Most are simply delivering their lines with confidence. So breathe... remain curious... and try not to interpret every temporary confusion as evidence of permanent inadequacy. In less philosophical language: relax a little.
Peter: Things only get busier, so take the time now to enjoy life around you. Every struggle is really just a new opportunity to learn.
What's one piece of advice for students entering the program?
Mahmoud: Try everything... Explore unfamiliar methods, attend talks beyond your immediate field, speak with people whose work you do not yet understand, and permit yourself to be rather poor at something before deciding whether you enjoy it. Discover what awakens your curiosity and what quietly extinguishes it. Knowing what you dislike is not a failure of direction... it is one of the ways direction is found. A career is rarely uncovered like buried treasure. It is carved gradually from experience, error, fascination, disappointment, and the occasional fortunate accident.
Peter: Networking is an under-appreciated part of science. Talk with your cohort, make friends, talk with your labmates, and go to SOMA events to meet other students.
Thanks to Mahmoud and Peter for taking the time to share their experiences with Brainwaves.